Greene AS1, Hajduk SL2.
J Biol Chem. 2016 Feb 5;291(6):3063-75. doi: 10.1074/jbc.M115.680371. Epub 2015 Dec 8.Human innate immunity against the veterinary pathogen Trypanosoma brucei brucei is conferred by trypanosome lytic factors (TLFs), against which human-infective T. brucei gambiense and T. brucei rhodesiense have evolved resistance. TLF-1 is a subclass of high density lipoprotein particles defined by two primate-specific apolipoproteins: the ion channel-forming toxin ApoL1 (apolipoprotein L1) and the hemoglobin (Hb) scavenger Hpr (haptoglobin-related protein). Read More