Gao M1, Zhu X1, Wu L1, Qiu L2.
Biomacromolecules. 2016 Jun 13;17(6):2199-209. doi: 10.1021/acs.biomac.6b00433. Epub 2016 May 26.To circumvent the severe toxicity of the systemic delivery of IL-12 protein and the limits of local administration of IL-12 gene, we constructed a polymersome system for systemic delivery of recombinant murine IL-12 plasmid (pmIL-12) based on amphiphilic polyphosphazenes containing weakly cationic N,N-diisopropylethylenediamine (DPA) as hydrophobic groups and monomethoxy poly(ethylene glycol) (mPEG) as hydrophilic tails. Read More