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Home > Product > Material & Chemicals > Polymer/Macromolecule > N-Methylisatoic anhydride

N-Methylisatoic anhydride | CAS Number: 10328-92-4

Catalog Number
ACM10328924
Product Name
N-Methylisatoic anhydride
Structure
CAS Number
10328-92-4
EC Number
233-714-8
IUPAC Name
1-methyl-3,1-benzoxazine-2,4-dione
Synonyms
AKOS 226;MIA;N-METHYLISATOIC ANHYDRIDE;TIMTEC-BB SBB000196;1-Methyl-2H-3,1-benzoxazine-2,4(1H)-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-;4(1h)-dione,1-methyl-2h-1-benzoxazine-2;N-Methyl ia
Molecular Weight
177.16
Exact Mass
177.04300
Molecular Formula
C9H7NO3
Boiling Point
297.5ºC at 760 mmHg
Melting Point
165ºC
Flash Point
133.7ºC
Density
1.348 g/cm3
Purity
96%
Appearance
brownish chunks
SMILES
CN1C2=CC=CC=C2C(=O)OC1=O
InChIKey
KJMRWDHBVCNLTQ-UHFFFAOYSA-N
H-Bond Donor
0
H-Bond Acceptor
3
Safty Description
S24/25
Hazard Statements
Xi:Irritant;
WGK Germany
3
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1A biotin-conjugated pyridine-based isatoic anhydride, a selective room temperature RNA-acylating agent for the nucleic acid separation.

Ursuegui S1, Yougnia R, Moutin S, Burr A, Fossey C, Cailly T, Laayoun A, Laurent A, Fabis F.

Org Biomol Chem. 2015 Mar 28;13(12):3625-32. doi: 10.1039/c4ob02636e.

Isatoic anhydride derivatives, including a biotin and a disulfide linker were specifically designed for nucleic acid separation. 2'-OH selective RNA acylation, capture of biotinylated RNA adducts by streptavidin-coated magnetic beads and disulfide chemical cleavage led to isolation of highly enriched RNA samples from an initial 9/1 DNA-RNA mixture. Starting from the parent compound N-methylisatoic anhydride A which was used at 65 °C, we improved the extraction process by designing a new generation of isatoic anhydrides that are able to react under smoother conditions. Read More

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Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA