Varshosaz J1, Hassanzadeh F2, Aliabadi HS3, Khoraskani FR4, Mirian M3, Behdadfar B5.
Int J Biol Macromol. 2016 Dec;93(Pt A):1192-1205. doi: 10.1016/j.ijbiomac.2016.07.025. Epub 2016 Sep 28.The novel dual targeted nanoparticles loaded with doxorubicin (DOX) and magnetic nanoparticles (MNPs) were prepared for treatment of breast cancer. Nanoparticles were produced by a layer-by-layer technique and functionalized with a bioconjugate of chitosan-poly(methyl vinyl ether maleic acid)(PMVMA)-LHRH to target LHRH receptors. The successful production of chitosan-PMVMA copolymer and its conjugation to LHRH was confirmed by FTIR and 1HNMR spectroscopy. Read More