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Home > Product > Material & Chemicals > Polymer/Macromolecule > Methyl 2-(trifluoromethyl)acrylate

Methyl 2-(trifluoromethyl)acrylate | CAS Number: 382-90-1

Catalog Number
ACM382901
Product Name
Methyl 2-(trifluoromethyl)acrylate
Structure
CAS Number
382-90-1
Synonyms
METHYL 2-(TRIFLUOROMETHYL)ACRYLATE;METHYL-2-(TRIFLUOROMETHYL)PROPENOATE;Methyll 2-(trifluoromethyl)acrylate;METHYL 2-(TRIFLUOROMETHYL)ACRYLATE INHIBITED;2-(Trifluoromethyl)acrylic acid methyl ester;α-(Trifluoromethyl)acrylic acid methyl ester;Methyl 2-(tr
Molecular Weight
154.09
Molecular Formula
C5H5F3O2
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1Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.

Ryder T1, Walker GS, Goosen TC, Ruggeri RB, Conn EL, Rocke BN, Lapham K, Steppan CM, Hepworth D, Kalgutkar AS.

Chem Res Toxicol. 2012 Oct 15;25(10):2138-52. doi: 10.1021/tx300243v. Epub 2012 Sep 27.

Inhibition of intestinal and hepatic microsomal triglyceride transfer protein (MTP) is a potential strategy for the treatment of dyslipidemia and related metabolic disorders. Inhibition of hepatic MTP, however, results in elevated liver transaminases and increased hepatic fat deposition consistent with hepatic steatosis. Diethyl 2-((2-(3-(dimethylcarbamoyl)-4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)phenyl)acetoxy)methyl)-2-phenylmalonate (JTT-130) is an intestine-specific inhibitor of MTP and does not cause increases in transaminases in short-term clinical trials in patients with dyslipidemia. Read More

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA