Atack TC1, Cook SP1.
J Am Chem Soc. 2016 May 18;138(19):6139-42. doi: 10.1021/jacs.6b03157. Epub 2016 May 9.The use of low-cost manganese(II) bromide (MnBr2) and tetramethylethylenediamine (TMEDA) catalyzes the cross coupling of (bis)pinacolatodiboron with a wide range of alkyl halides, demonstrating the first manganese-catalyzed coupling with alkyl electrophiles. This method allows access to primary, secondary, and tertiary boronic esters from the parent chlorides, which were previously inaccessible as coupling partners. Read More