Makarov IS1, Madsen R.
J Org Chem. 2013 Jul 5;78(13):6593-8. doi: 10.1021/jo4008699. Epub 2013 Jun 13.The dehydrogenative self-condensation of primary and secondary alcohols has been studied in the presence of RuCl2(IiPr)(p-cymene). The conversion of primary alcohols into esters has been further optimized by using magnesium nitride as an additive, which allows the reaction to take place at a temperature and catalyst loading lower than those described previously. Secondary alcohols were dimerized into racemic ketones by a dehydrogenative Guerbet reaction with potassium hydroxide as the additive. Read More