Gorbunov A1, Sokolova N1, Kudryashova E1, Nenajdenko V1, Kovalev V1, Vatsouro I2.
Chemistry. 2016 Aug 22;22(35):12415-23. doi: 10.1002/chem.201601818. Epub 2016 Jul 22.Cone calixarenes and calixarenes bearing two, three, and four short peptide units each having two chiral carbon atoms were prepared. The syntheses were performed by using an efficient modular approach that includes the Ugi preparation of the azido-peptide followed by its reactions with the propargylated calixarenes under CuAAC (Cu(I) -catalyzed azide-alkyne cycloaddition) conditions. The three novel multitopic hosts were probed for their ability to bind metal ions by UV titration, and showed the highest complexation efficiency towards copper(II) and lead(II). Read More