Latanoprost

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Catalog Number
ACM130209824
Product Name
Latanoprost
Structure
Structure
CAS
130209-82-4
Category
Main Products
Description
Latanoprost eye solution is a medication administered into the eyes to control the progression of glaucoma or ocular hypertension by reducing intraocular pressure (IOP). It is a prostaglandin analogue (more specifically an analogue of prostaglandin F2α) that lowers the pressure by increasing the outflow of aqueous fluid from the eyes through the uveoscleral tract. Latanoprost is an isopropyl ester prodrug, meaning it is inactive until it is hydrolyzed by esterases in the cornea to the biologically active acid.Latanoprost was invented by Johan W. Stjernschantz and Bahram Resul, employees of the Pharmacia Corporation of Uppsala, Sweden. It is on the World Health Organization’s List of Essential Medicines, a list of the most important medication needed in a basic health system. It is also known by the brand name of Xalatan manufactured by Pfizer. Annual sales are approximately $1.6 billion. The patent for latanoprost expired in March 2011, and at least one generic version is now widely available in the U.S.
Synonyms
Isopropyl (5Z,9Α,11Α,15R)-9,11,15-Trihydroxy-17-Phenyl-18,19,20-Trinor-Prost-5-En-1-Oate
Molecular Weight
432.59
Molecular Formula
C26H40O5
Canonical SMILES
CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
Boiling Point
583.8 °C at 760 mmHg (Predicted)
Flash Point
188.3ºC
Density
1.093 g/cm³
Appearance
Oil
HS Code
2937500000
LogP
4.18640
PSA
86.99
Refractive Index
1.537
Storage Conditions
-20ºC
WGK Germany
3
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