Skrzypski M1, Khajavi N2, Mergler S3, Billert M4, Szczepankiewicz D4, Wojciechowicz T4, Nowak KW4, Strowski MZ5,6.
J Physiol Pharmacol. 2016 Oct;67(5):643-652.Orexins A (OXA) and B (OXB) control energy homeostasis by regulating food intake, energy expenditure and sleep-wake cycle. Several studies showed that OXA stimulates insulin secretion and proliferation of beta cells. However, mechanisms of action are still not well understood. Here, we investigated whether ERK and transient receptor potential channels (TRPs) play a role in mediating the effect of OXA on cell growth, insulin production, and secretion using the established INS-1E cell line. Read More