Moon JY1, Choi SR2, Roh DH3, Yoon SY4, Kwon SG2, Choi HS2, Kang SY1, Han HJ2, Kim HW5, Beitz AJ6, Oh SB4, Lee JH7.
Pharmacol Res. 2015 Oct;100:353-64. doi: 10.1016/j.phrs.2015.08.019. Epub 2015 Aug 24.We have previously demonstrated that activation of the spinal sigma-1 receptor (Sig-1R) plays an important role in the development of mechanical allodynia (MA) via secondary activation of the N-methyl-d-aspartate (NMDA) receptor. Sig-1Rs have been shown to localize to astrocytes, and blockade of Sig-1Rs inhibits the pathologic activation of astrocytes in neuropathic mice. However, the mechanism by which Sig-1R activation in astrocytes modulates NMDA receptors in neurons is currently unknown. Read More