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Home > Product > Material & Chemicals > Micro/NanoElectronics > L-Serine O-sulfate potassium salt

L-Serine O-sulfate potassium salt | CAS Number: 17436-02-1

Catalog Number
ACM17436021
Product Name
L-Serine O-sulfate potassium salt
Structure
CAS Number
17436-02-1
Synonyms
L-SERINE O-SULFATE POTASSIUM SALT;L-SERINE O-SULFATE POTASSIUM
Molecular Weight
223.25
Molecular Formula
C3H6KNO6S
Purity
≥98%
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1Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.

Moon JY1, Choi SR2, Roh DH3, Yoon SY4, Kwon SG2, Choi HS2, Kang SY1, Han HJ2, Kim HW5, Beitz AJ6, Oh SB4, Lee JH7.

Pharmacol Res. 2015 Oct;100:353-64. doi: 10.1016/j.phrs.2015.08.019. Epub 2015 Aug 24.

We have previously demonstrated that activation of the spinal sigma-1 receptor (Sig-1R) plays an important role in the development of mechanical allodynia (MA) via secondary activation of the N-methyl-d-aspartate (NMDA) receptor. Sig-1Rs have been shown to localize to astrocytes, and blockade of Sig-1Rs inhibits the pathologic activation of astrocytes in neuropathic mice. However, the mechanism by which Sig-1R activation in astrocytes modulates NMDA receptors in neurons is currently unknown. Read More

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA