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Home > Product > Heterocyclic Organic Compounds > Isoquinoline-4-boronic acid hydrochloride

Isoquinoline-4-boronic acid hydrochloride | CAS Number: 677702-23-7

Catalog Number
ACM677702237
Product Name
Isoquinoline-4-boronic acid hydrochloride
Structure
CAS Number
677702-23-7
Synonyms
ISOQUINOLINE-4-BORONIC ACID HYDROCHLORIDE;ISOQUINOLIN-4-YLBORONIC ACID HYDROCHLORIDE;4-Isoquinolineboronic acid hydrochloride;4-Isoquinolinyl-boronic acid hydrochloride
Molecular Weight
209.43726
Molecular Formula
C9H9BClNO2
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1Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C1, Carpintero M1, Diego JE1, Barberis M1, Garcia-Cerrada S1, Sori

J Med Chem. 2016 Dec 22;59(24):10974-10993. Epub 2016 Dec 6.

As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3. Read More

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Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA