Kerai LV1, Hilton S1, Maugueret M2, Kazi BB2, Faull J2, Bhakta S2, Murdan S3.
Int J Pharm. 2016 Nov 30;514(1):244-254. doi: 10.1016/j.ijpharm.2016.08.025.UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. However, ethanol inclusion in the pharmaceutical formulation (to enable drug loading) reduced the in vivo residence. The second aim was therefore to determine any other effects of ethanol, and if ethanol could be avoided by the choice of monomers. Read More