Grem JL1, Wright M1, Morrison G1, Lin PX1, Leonard G1, Nguyen D1, Guo XD1, Szabo E1; NCI-Navy GI Tumor Clinical Group.
J Clin Oncol. 2004 Jul 15;22(14_suppl):2075.2075 Background: Preclinical studies show that initial exposure to IR prior to FU is superior to concurrent exposure or the reverse sequence. IR given over 24h may be better tolerated than 0.5-1.5h infusions.METHODS: 32 patient (pts) with GI tract cancers participated. IR was initially given at 4 levels (70-140 mg/m2/24h ) followed by LV 500 mg/m2/0.5h & FU 2000 mg/m2/48h starting d 1 & 15 of a 4-wk cycle. Read More