Zhang L1, Li Z, Liu ZQ.
Org Lett. 2014 Jul 18;16(14):3688-91. doi: 10.1021/ol5014747. Epub 2014 Jul 1.An I(2)O(5)-promoted free-radical cascade trifluoromethylation/cyclization of a broad range of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate in aqueous medium has been achieved. This strategy allows highly selective access to a variety of CF(3)-containing oxindoles and pyrrolidines. Electron spin resonance (ESR) studies indicate that atom-transfer processes are involved in this system.