Choi JM1, Jeong WS, Park EJ, Choi JW.
J Craniofac Surg. 2016 Dec 28. doi: 10.1097/SCS.0000000000003344. [Epub ahead of print]Bone morphogenetic protein-2 (BMP-2) appears to be one of the most potent growth factors thus far studied. However, recent publications on the clinical application of BMP-2 revealed that its correct control is the paramount issue in clinical practice. For improving BMP-2 delivery, the cyclic administration might be an alternative. Accordingly, the authors cyclically injected BMP-2 in a cyclic injection model of large cranial defects to maintain the proper dosage during the bone healing process. Read More