Cronin SA1, Gutiérrez Collar A, Gundala S, Cornaggia C, Torrente E, Manoni F, Botte A, Twamley B, Connon SJ.
Org Biomol Chem. 2016 Aug 7;14(29):6955-9. doi: 10.1039/c6ob00048g. Epub 2016 Jul 6.The first catalytic, asymmetric reactions of imines with homophthalic anhydride to form disubstituted 3,4-dihydroisoquinolones are reported. The use of N-mesyl aldimines is key, as more basic imines undergo rapid uncatalysed reactions, while imines possessing larger N-sulphonyl substituents form lactams with lower ee.