Pan JL1, Li QZ, Zhang TY, Hou SH, Kang JC, Zhang SY.
Chem Commun (Camb). 2016 Nov 18;52(89):13151-13154. Epub 2016 Oct 20.An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp3)-H bonds to form C-Si bonds with hexamethyldisilane (HMDS). This method highlights the emerging strategy to transform unactivated methyl or methylene into versatile functional groups in organic synthesis and provides a new method to construct functionalized C-Si bonds for synthetic chemistry.