Bonvalot S1, Le Pechoux C2, De Baere T2, Kantor G3, Buy X3, Stoeckle E3, Terrier P2, Sargos P3, Coindre JM3, Lassau N2, Ait Sarkouh R4, Dimitriu M4, Borghi E4, Levy L4, Deutsch E2, Soria JC2.
Clin Cancer Res. 2016 Oct 6. doi: 10.1158/1078-0432.CCR-16-1297. [Epub ahead of print]PURPOSE: This phase I study aimed to determine the recommended dose (RD), safety profile, and feasibility of a procedure combining intratumoral injection of hafnium oxide nanoparticles (NBTXR3; a radioenhancer) and external beam radiotherapy (EBRT) for preoperative treatment of adults with locally advanced soft tissue sarcoma (STS).EXPERIMENTAL DESIGN: Patients had a preoperative indication of EBRT for STS of the extremity or trunk. Read More