Ho CH1, Odermatt EK, Berndt I, Tiller JC.
J Biomater Sci Polym Ed. 2013;24(13):1589-600. doi: 10.1080/09205063.2013.782803. Epub 2013 Apr 10.The goal of this study was to develop a long-term active antimicrobial coating for surgical sutures. To this end, two water-insoluble polymeric nanocontainers based on hyperbranched polylysine (HPL), hydrophobically modified by either using glycidyl hexadecyl ether, or a mixture of stearoyl/palmitoyl chloride, were synthesized. Highly stabilized silver nanoparticles (AgNPs, 2-5 nm in size) were generated by dissolving silver nitrate in the modified HPL solutions in toluene followed by reduction with L-ascorbic acid. Read More