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Glutaric anhydride | CAS Number: 108-55-4

Catalog Number
ACM108554
Product Name
Glutaric anhydride
Structure
CAS Number
108-55-4
Synonyms
2H-Pyran-2,6(3H)-dione,dihydro-;6(3H)-dione,dihydro-2H-Pyran-2;Anhydrid kyseliny glutarove;anhydridkyselinyglutarove;dihydro-2h-pyran-6(3h)-dione;Glutaric acid anhydride;glutaricacidanhydride;Pentanedioic anhydride
Molecular Weight
114.1
Molecular Formula
C5H6O3
Purity
MP 54-56deg
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1Design of a doxorubicin-peptidomimetic conjugate that targets HER2-positive cancer cells.

Pallerla S1, Gauthier T2, Sable R1, Jois SD3.

Eur J Med Chem. 2017 Jan 5;125:914-924. doi: 10.1016/j.ejmech.2016.10.015. Epub 2016 Oct 10.

Doxorubicin (DOX) belongs to the anthracycline class of drugs that are used in the treatment of various cancers. It has limited cystostatic effects in therapeutic doses, but higher doses can cause cardiotoxicity. In the current approach, we conjugated a peptidomimetic (Arg-aminonaphthylpropionic acid-Phe, compound 5) known to bind to HER2 protein to DOX via a glutaric anhydride linker. Antiproliferative assays suggest that the DOX-peptidomimetic conjugate has activity in the lower micromolar range. Read More

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Email:
Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA