Wang Y1, Song R2, Feng H3, Guo K4, Meng Q5, Chi H6, Zhang R7,8, Zhang Z9.
Sensors (Basel). 2016 Dec 16;16(12). pii: E2165. doi: 10.3390/s16122165.A new Gadolinium(III)-coumarin complex, DO3A-Gd-CA, was designed and prepared as a dual-modal probe for simultaneous fluorescence and relaxivity responses to fluoride ions (F-) in aqueous media and mice. DO3A-Gd-CA was designed by using Gd(III) center as an MRI signal output unit and fluoride binding site, and the 4-(diethylamino)-coumarin-3-carboxylic acid (CA) as a fluorescence reporter. Upon the addition of fluoride ions to the solution of DO3A-Gd-CA, the liberation of the coordinated CA ligand led to a 5. Read More