Li X1, Ma J2, Shi W2, Su Y3, Fu X2, Yang Y2, Lu J2, Yue Z2.
Oxid Med Cell Longev. 2016;2016:5203801. Epub 2016 Nov 14.Objective. To investigate whether calcium-sensing receptor (CaSR) plays a role in calcium-oxalate-induced renal injury. Materials and Methods. HK-2 cells and rats were treated with calcium oxalate (CaOx) crystals with or without pretreatment with the CaSR-specific agonist gadolinium chloride (GdCl3) or the CaSR-specific antagonist NPS2390. Changes in oxidative stress (OS) in HK-2 cells and rat kidneys were assessed. Read More