Catalog Number
ACM23110158
Description
Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV-1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
Synonyms
NSC9168; NSC 9168; NSC-9168; Fumidil B; Fumagillin, trade name: Fumagilina; Fugillin; Fumidil.
IUPAC Name
(2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid
Molecular Weight
458.55 g/mol
Molecular Formula
C26H34O7
Canonical SMILES
O=C(O)/C=C/C=C/C=C/C=C/C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)OC2C/C=C(C)\C)[C@]31CO3)=O
InChI
InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20?,23-,24-,25+,26+/m1/s1
InChI Key
NGGMYCMLYOUNGM-IJIYPQOHSA-N
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Drug Formulation
This drug may be formulated in DMSO
Elemental Analysis
C, 68.10; H, 7.47; O, 24.42
HS Tariff Code
2934.99.9001
Safety Description
36-36/37-16
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Supplemental Hazard Statements
H225-H302-H312-H319-H332