Jiang G1, Li R1, Tang J1, Ma Y1, Hou X1, Yang C2, Guo W3, Xin Y3, Liu Y1.
Oncol Rep. 2016 Dec 29. doi: 10.3892/or.2016.5342. [Epub ahead of print]The present study was carried out to prepare and evaluate a temozolomide (TMZ)-loaded polyamide-amine dendrimer (PAMAM)‑based nanodrug delivery system, and to explore its ability to target human melanoma (A375) cells in vitro. Firstly, PAMAM-PEG and PAMAM-PEG-GE11 were synthesized by substitution and addition reactions, and their products were identified and characterized by fourier transform-infrared (FTIR), proton nuclear magnetic resonance (1H-NMR) and transmission electron microscopy (TEM), as well as differential light scattering (DLS). Read More