Floxuridine

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Catalog Number
ACM50919
Product Name
Floxuridine
Structure
Structure
CAS
50-91-9
Category
Inhibitors
Description
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
Synonyms
1-beta-d-2'-deoxyribofuranosyl-5-flurouracil;1beta-D-2-Deoxyribofuranosyl-5-fluorouracil;2'-deoxy-5-fluoro-uridin;5-fluor-1-(beta-2'-deoxyribofuranosyl)pyrimidin-2,4(1h,3h)-dion;5-Fluor-1-(beta-2-deoxyribofuranosyl)pyrimidin-2,4(1H,3H)-dion;5-Fluoro-2-deoxyiridine;5-Fluorouracil 2-deoxyriboside;5-Fluorouracil deoxyriboside
Molecular Weight
246.19
Molecular Formula
C9H11FN2O5
Boiling Point
150°C
Melting Point
148°C(lit.)
Hazard Statements
Xn,T,Xi
Safety Description
22-36-36/37/39-26
Supplemental Hazard Statements
H302-H341-H360-H301
Symbol
GHS06,GHS07,GHS08
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