Ferro M1, Castiglione F1, Punta C1, Melone L2, Panzeri W3, Rossi B4, Trotta F5, Mele A6.
J Vis Exp. 2016 Aug 15;(114). doi: 10.3791/53769.The chemical cross-linking of β-cyclodextrin (β-CD) with ethylenediaminetetraacetic dianhydride (EDTA) led to branched polymers referred to as cyclodextrin nanosponges (CDNSEDTA). Two different preparations are described with 1:4 and 1:8 CD-EDTA molar ratios. The corresponding cross-linked polymers were contacted with 0.27 M aqueous solution of ibuprofen sodium salt (IP) leading to homogeneous, colorless, drug loaded hydrogels. Read More