Pujari-Palmer M1, Pujari-Palmer S1, Lu X1, Lind T2, Melhus H2, Engstrand T3,4, Karlsson-Ott M1, Engqvist H1.
PLoS One. 2016 Oct 4;11(10):e0163530. doi: 10.1371/journal.pone.0163530. eCollection 2016.Pyrophosphate is a potent mitogen, capable of stimulating proliferation in multiple cell types, and a critical participant in bone mineralization. Pyrophosphate can also affect the resorption rate and bioactivity of orthopedic ceramics. The present study investigated whether calcium pyrophosphate affected proliferation, differentiation and gene expression in early (MC3T3 pre-osteoblast) and late stage (SAOS-2 osteosarcoma) osteoblasts. Read More