Su X1, Wang X, Zhang K, Yang S, Liu Q, Leung AW, Xu C, Wang P.
Gen Physiol Biophys. 2016 Apr;35(2):155-64. doi: 10.4149/gpb_2015051. Epub 2016 Feb 18.Sonodynamic therapy (SDT) is expected to be a novel therapeutic strategy for tumor. The protoporphyrin IX disodium salt (PpIX), a photosensitizer, can be activated by ultrasound. The present study aims to investigate apoptosis of HL-60 cells induced by PpIX-mediated SDT. 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was adopted to examine cell toxicity. Apoptosis was detected using Annexin V-PE/7-amino-actinomycin D (7-AAD) double staining. Read More