Antonenko YN1, Denisov SS2, Khailova LS3, Nazarov PA3, Rokitskaya T3, Tashlitsky VN4, Firsov AM3, Korshunova GA3, Kotova EA5.
Biochim Biophys Acta. 2016 Dec 20. pii: S0005-2736(16)30407-2. doi: 10.1016/j.bbamem.2016.12.014. [Epub ahead of print]In search for new effective uncouplers of oxidative phosphorylation, we studied 4-aryl amino derivatives of a fluorescent group 7-nitrobenz-2-oxa-1,3-diazol (NBD). In our recent work (Denisov et al., Bioelectrochemistry, 2014), NBD-conjugated alkyl amines (NBD-Cn) were shown to exhibit uncoupling activity. It was concluded that despite a pKa value being about 10, the expected hindering of the uncoupling activity could be overcome by insertion of an alkyl chain. Read More