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Diethyl azelate | CAS Number: 624-17-9

Catalog Number
ACM624179
Product Name
Diethyl azelate
Structure
CAS Number
624-17-9
Synonyms
DIETHYL AZELATE;AKOS 223-29;Azelaic acid, diethyl ester;Diethyl azelaate;Diethyl nonanedioate;Nonanedioic acid, diethyl ester;Nonanedioicacid,diethylester;nonanedioicaciddiethylester
Molecular Weight
244.33
Molecular Formula
C13H24O4
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1A prodrug approach to enhance azelaic acid percutaneous availability.

Al-Marabeh S1, Khalil E2, Khanfar M1, Al-Bakri AG2, Alzweiri M1,3.

Pharm Dev Technol. 2016 Jun 27:1-9. [Epub ahead of print]

Azelaic acid is a dicarboxylic acid compound used in treatment of acne vulgaris. However, high concentration (ca 20%) is needed to guarantee the drug availability in the skin. The latter increases the incidence of side effects such as local irritation. The prodrug strategy to enhance azelaic acid diffusion through skin was not reported before. Thus, a lipophilic prodrug of azelaic acid (diethyl azelate [DEA]) was synthesized and investigated to improve percutaneous availability of azelaic acid, with a subsequent full physical, chemical, and biological characterization. Read More

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Email:
Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA