Schmitz C1, Leitner W2, Franciò G3.
Chemistry. 2015 Jul 20;21(30):10696-702. doi: 10.1002/chem.201500352. Epub 2015 May 26.A library of α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL)-based phosphoramidites has been synthesized and applied in the Ni-catalyzed cycloisomerization of different dienes. Through the systematic variation of the three structural motifs of the lead structure, that is, the amine moiety, the protecting group, and the aryl substituents, the ligand features could be optimized for the asymmetric cycloisomerization of the model substrate diethyl diallylmalonate. Read More