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Home > Product > Material & Chemicals > Polymer/Macromolecule > Diethyl 2,5-dihydroxyterephthalate

Diethyl 2,5-dihydroxyterephthalate | CAS Number: 5870-38-2

Catalog Number
ACM5870382
Product Name
Diethyl 2,5-dihydroxyterephthalate
Structure
CAS Number
5870-38-2
Synonyms
DIETHYL 2,5-DIHYDROXYTEREPHTHALATE;1,4-Benzendicarboxylicacid,2,5-dihydroxy-,diethylester;4-benzenedicarboxylicacid,2,5-dihydroxy-diethylester;DIETHYL 2 5-DIHYDROXYTEREPHTHALATE98%;2,5-Dihydroxyterephthalic acid diethyl ester;2,5-Dihydroxy-1,4-benzenedica
Molecular Weight
254.24
Molecular Formula
C12H14O6
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1Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.

Ahmadibeni Y1, Tiwari R2, Swepson C3, Pandhare J3, Dash C3, Doncel GF4, Parang K2.

Tetrahedron Lett. 2011 Feb 16;52(7):802-805. Epub 2010 Dec 15.

Anti-HIV nucleoside monophosphates have limited cellular uptake due to the presence of negatively-charged phosphate group. Bis-(cycloSaligenyl) derivatives containing two anti-HIV nucleosides, 3'-fluoro-3'-deoxythymidine (FLT) and 3'-azido-3'-deoxythymidine (AZT) were synthesized to increase intracellular delivery of nucleoside monophosphates. 2,5-Bis(hydroxymethylene)benzene-1,4-diol was selected as a monocyclic bidentate scaffold and synthesized by three different methods from bis(hydroxymethylene)cyclohexan-1,4-diene-1,4-diol, or diethyl 2,5-dihydroxyterephthalate. Read More

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