Morel B, Franck P, Bidange J, Sergeyev S, Smith D, Moseley J, Maes BU1.
ChemSusChem. 2016 Nov 29. doi: 10.1002/cssc.201601483. [Epub ahead of print]A novel and concise route towards xanthines via a double amidination reaction is described; consecutive intermolecular C-Cl and intramolecular oxidative C-H amidination. N-uracil amidines are obtained via SNAE on a 6-chlorouracil with amidines. Direct Cu-catalyzed oxidative C-H amidination on these N-uracil amidines yields polysubstituted xanthines. Sustainable oxidants, di-tert-butyl peroxide or oxygen, can be used in this oxidase type reaction. Read More