Xu C, Huang Y, Tang L, Hong Y.
ACS Appl Mater Interfaces. 2016 Dec 30. doi: 10.1021/acsami.6b15009. [Epub ahead of print]The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low initial moduli with a J-shaped tensile curve. The suitable synthetic polymer scaffolds requires low initial modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-ε-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer PVCL-PEG-PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes with low initial moduli. Read More