Prasad SS1, Kumar KS, Jayaprakash SH, Krishna BS, Sundar CS, Rao PV, Babu TM, Rajendra W, Reddy CS.
Arch Pharm (Weinheim). 2013 May;346(5):380-91. doi: 10.1002/ardp.201300032. Epub 2013 Apr 16.A series of new diethyl(alkyl/aryl/heteroarylamino)(4-(pyridine-2-yl)phenyl)methylphosphonates (4a-t) were synthesized via three-component Kabachnik-Field's reaction of 4-(pyridin-2-yl)benzaldehyde, diethylphosphite and various primary amines, catalyzed by cupric acetate monohydrate [Cu(OAc)(2) ∙ H(2)O] under solvent-free and microwave irradiation conditions. Their computational docking analysis supported them as good therapeutic agents to the breast cancer aromatase enzyme and ascertained 4a, 4h, 4m, 4n, and 4t as potential molecules with good binding affinities varying from -9. Read More