Portas Ados S1, Miguel DC, Yokoyama-Yasunaka JK, Uliana SR, Espósito BP.
J Biol Inorg Chem. 2012 Jan;17(1):107-12. doi: 10.1007/s00775-011-0834-3. Epub 2011 Aug 25.Copper complexes with fluorinated β-diketones were synthesized and characterized in terms of lipophilicity and peroxide-assisted oxidation of dihydrorhodamine as an indicator of redox activity. The biological activity of the complexes was tested against promastigotes of Leishmania amazonensis. Inhibition of trypanosomatid-specific trypanothione reductase was also tested. It was found that the highly lipophilic and redox-active bis(trifluoroacetylacetonate) derivative had increased toxicity towards promastigotes. Read More