Yaku H1, Murashima T, Tateishi-Karimata H, Nakano S, Miyoshi D, Sugimoto N.
Methods. 2013 Nov;64(1):19-27. doi: 10.1016/j.ymeth.2013.03.028. Epub 2013 Apr 2.The telomere G-quadruplex-binding and telomerase-inhibiting capacity of two cationic (TMPyP4 and PIPER) and two anionic (phthalocyanine and Hemin) G-quadruplex-ligands were examined under conditions of molecular crowding (MC). Osmotic experiments showed that binding of the anionic ligands, which bind to G-quadruplex DNA via π-π stacking interactions, caused some water molecules to be released from the G-quadruplex/ligand complex; in contrast, a substantial number of water molecules were taken up upon electrostatic binding of the cationic ligands to G-quadruplex DNA. Read More