Santos D1,2, González-Pérez F3,4, Giudetti G5, Micera S6,7, Udina E8,9, Del Valle J10,11, Navarro X12,13.
Int J Mol Sci. 2016 Dec 29;18(1). pii: E65. doi: 10.3390/ijms18010065.After peripheral nerve injury, motor and sensory axons are able to regenerate but inaccuracy of target reinnervation leads to poor functional recovery. Extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert their effect on different neuronal populations creating a suitable environment to promote axonal growth. Here, we assessed in vitro and in vivo the selective effects of combining different ECM components with NTFs on motor and sensory axons regeneration and target reinnervation. Read More