Lopez-Manzano E1, Cronican AA1, Frawley KL1, Peterson J1, Pearce LL1.
Chem Res Toxicol. 2016 Jun 20;29(6):1011-9. doi: 10.1021/acs.chemrestox.6b00070. Epub 2016 May 26.The complex of cobalt(II) with the ligand 2,12-dimethyl-3,7,11,17-tetraazabicyclo-[11.3.1]heptadeca-1(17)2,11,13,15-pentaene (CoN4[11.3.1]) has been shown to bind two molecules of cyanide in a cooperative fashion with an association constant of 2.7 (±0.2) × 10(5). In vivo, irrespective of whether it is initially administered as the Co(II) or Co(III) cation, EPR spectroscopic measurements on blood samples show that at physiological levels of reductant (principally ascorbate) CoN4[11. Read More