Nithipatikom K1, Endsley MP1, Pfeiffer AW1, Falck JR2, Campbell WB1.
J Lipid Res. 2014 Oct;55(10):2093-102. doi: 10.1194/jlr.M051284. Epub 2014 Jun 23.Microsomal epoxide hydrolase (EPHX1, EC 126.96.36.199) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity. A wide range of EPHX1 functions have been demonstrated including xenobiotic metabolism; however, characterization of its endogenous substrates is limited. In this study, we present evidence that EPHX1 metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. Read More