Bartholomäus R1, Irwin JA, Shi L, Smith SM, Levina A, Lay PA.
Inorg Chem. 2013 Apr 15;52(8):4282-92. doi: 10.1021/ic3022408. Epub 2013 Mar 26.The stabilization of Cr(V) by biological 1,2-diolato ligands, including carbohydrates, glycoproteins, and sialic acid derivatives, is likely to play a crucial role in the genotoxicity of Cr(VI) and has also been implicated in the antidiabetic effect of Cr(III). Previously, such complexes have been observed by electron paramagnetic resonance (EPR) spectroscopy in living cells or animals, treated with carcinogenic Cr(VI), as well as in numerous model systems, but attempts to isolate them have been elusive. Read More