Fmoc-TOAC-OH

Catalog Number

ACM93372259-1

Product Name

Fmoc-TOAC-OH

Structure

CAS

93372-25-9

Category

Amino Acids

Description

Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences by Fmoc SPPS. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment.

Synonyms

Fmoc-TOAC-OH, 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-(9-fluorenylmethyloxycarbonyl-amino)-4-carboxylic acid

Molecular Weight

437.51

InChI

1S/C25H29N2O5/c1-23(2)14-25(21(28)29,15-24(3,4)27(23)31)26-22(30)32-13-20-18-11-7-5-9-16(18)17-10-6-8-12-19(17)20/h5-12,20H,13-15H2,1-4H3,(H,26,30)(H,28,29)

InChI Key

FAQWDTRJLKQJBN-UHFFFAOYSA-N

Application

Peptide synthesis.

Assay

≥98.0% (HPLC)

Form

powder

Functional Group

Fmoc

Quality Level

200

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Storage Temperature

2-8℃

MSDS

COA

Spec Sheet