Bafilomycin c1

Catalog Number

ACM88979617

Product Name

Bafilomycin c1

Structure

CAS

88979-61-7

Category

Inhibitors

Description

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC).

Synonyms

BAFILOMYCIN C1;2-Demethyl-2-methoxy-24-methylhygrolidin;Antibiotic L-681110A1;L-681110A1

IUPAC Name

4-[2-hydroxy-2-[3-hydroxy-4-(10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl)pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid

Molecular Weight

720.8865

Molecular Formula

C₃₉H₆₀O₁₂

Canonical SMILES

CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)O)O)O)OC)C

InChI Key

WUDBXVQNMOTFEE-UHFFFAOYSA-N

Boiling Point

844.4ºC at 760 mmHg

Flash Point

248.9ºC

Density

1.18 g/cm³

Appearance

Light tan solid

Exact Mass

720.40800

H-Bond Acceptor

12

H-Bond Donor

4

MSDS

COA

Spec Sheet