1,8-Dihydroxy-4,5-dinitroanthraquinone

Catalog Number

ACM81550

Product Name

1,8-Dihydroxy-4,5-dinitroanthraquinone

Structure

CAS

81-55-0

Category

Inhibitors

Description

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.

Molecular Weight

330.21

Molecular Formula

C₁₄H₆N₂O₈

Canonical SMILES

O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O

Appearance

Solid

Storage

Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.

Shipping

Can be shipped at room temperature, where not in use may vary.

MSDS

COA

Spec Sheet