Description
Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Metoprine is an antifolate and antitumor agent.
Synonyms
5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(3,4-
dichlorophenyl)-6-methylpyrimidine; 2,4-Diamino-5-(3',4'-dichlorophenyl)-
6-methylpyrimidine; BW 197U; BW 50197; DDMP; Methodichlorophen; NSC 19494; NSC 7364; SK 5265; U 197;
IUPAC Name
5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine
Molecular Formula
C11H10Cl2N4
Canonical SMILES
CC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl
InChI Key
VQJHOPSWBGJHQS-UHFFFAOYSA-N
Boiling Point
483.7ºC at 760 mmHg
Storage
Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
Shipping
Can be shipped at room temperature, where not in use may vary.
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