Latrunculin A

Catalog Number

ACM76343936

Product Name

Latrunculin A

CAS

76343-93-6

Category

Inhibitors

Description

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.

Molecular Weight

421.55

Molecular Formula

C22H31NO5S

Canonical SMILES

O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

Appearance

Liquid

Storage

Solution, -20°C, 2 years

Shipping

Can be shipped at room temperature, where not in use may vary.

Source

Red sea sponge Latrunculia magnifica

MSDS

COA

Spec Sheet