Catalog Number
ACM66640866
Product Name
Biotin hydrazide
Category
Heterocyclic Organic Compound
Description
Biotin hydrazide is a biotinyl derivative that can be used as a probe for the determination of protein carbonylation, which is a component of several diseases. Protein carbonylation, an irreversible post translational modification (PTM), is caused by attack of reactive oxygen species (ROS), numerous lipid oxidation products (such as α,β-unsaturated γ-hydroxyalkenals), or nonemzymatic glycation resulting in the loss of protein function. Biotin hydrazide is a preferred carbonyl-reactive probe for its direct reaction and chemistry and no requirement of additional catalysts or reducing agents. Biotin hydrazide exclusively and readily derivatizes carbonyl groups at pH 5.5, which facilitates its use to measure carbonylated proteins in biological samples.
Synonyms
(+)-Biotin Hydrazide; Biotin-Hz; Hydrazide Biotin; Biotine Hydrazide
IUPAC Name
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide
Molecular Weight
258.3 g/mol
Molecular Formula
C10H18N4O2S
Canonical SMILES
C1C2C(C(S1)CCCCC(=O)NN)NC(=O)N2
InChI Key
KOZWHQPRAOJMBN-ZKWXMUAHSA-N
Boiling Point
633.1ºC at 760 mmHg
Appearance
white or slightly yellow powder
Shipping
Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.