Aphidicolin

Catalog Number

ACM38966211

Product Name

Aphidicolin

Structure

CAS

38966-21-1

Category

Inhibitors

Description

Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.

Molecular Weight

338.48

Molecular Formula

C₂₀H₃₄O₄

Canonical SMILES

C[C@@]12[C@]34[C@](CC[C@@]1([H])[C@@](C)([C@H](O)CC2)CO)([H])C[C@]([C@](CO)(O)CC4)([H])C3

Appearance

Solid

Storage

Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.

Shipping

Can be shipped at room temperature, where not in use may vary.

Source

Cephalosporium aphidicola

MSDS

COA

Spec Sheet