Nsc 663284

Catalog Number

ACM383907435

Product Name

Nsc 663284

Structure

CAS

383907-43-5

Category

Inhibitors

Description

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM).

Molecular Weight

321.762

Molecular Formula

C₁₅H₁₆ClN₃O₃

Canonical SMILES

O=C(C(Cl)=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O

Appearance

Solid

Storage

Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.

Shipping

Can be shipped at room temperature, where not in use may vary.

MSDS

COA

Spec Sheet